Small Molecule Inhibitors of Acid Sphingomyelinase

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Small molecule inhibitors of acid sphingomyelinase.

Despite of the importance of the acid sphingomyelinase for sphingomyelin homeostasis and sphingolipid signalling, potent and selective inhibitors for this enzyme are rare. An increasing set of data on the inhibition of acid sphingomyelinase in different disease models using indirect inhibitors has been generated and strongly implies acid sphingomyelinase as an emerging drug target. Very recentl...

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ژورنال

عنوان ژورنال: Cellular Physiology and Biochemistry

سال: 2010

ISSN: 1421-9778,1015-8987

DOI: 10.1159/000315100